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Ole Gunnar Solskjaer and Unai Emery both have some big calls to make as Manchester United host Arsenal in a huge Monday night Premier League clash.
Anthony Martial, Paul Pogba and Marcus Rashford are all injury doubts for United in what already looks like a vital match for the under-pressure Solskjaer.
United go into the game 13 points adrift of leaders Liverpool, albeit with a game in hand, and the Red Devils can ill-afford a slip-up against a direct top-four rival.
Unfortunately for Solskjaer, the Norweigian is set to be without a host of key players: Pogba returned for Wednesday’s EFL Cup win against Rochdale following an ankle injury, but suffered another setback and currently has a swollen ankle.
Martial is also a doubt due to the thigh injury which has kept him out since the home defeat to Crystal Palace, while Rashford suffered a groin strain in last week’s 2-0 defeat to West Ham and looks set to lose his race to be fit.
That could mean Mason Greenwood earning his first Premier League start of the season: the 17-year-old has scored in successive games against Astana and Rochdale and is now pressing to be included.
As for Arsenal, Emery has several defensive options at his disposal: Hector Bellerin, Rob Holding and Kieran Tierney all made their long-awaited returns from injury in Tuesday’s comfortable EFL Cup win over Nottingham Forest.
The Spaniard hinted Monday may come too soon for Bellerin to play 90 minutes at such a difficult venue and if taken at his word, he must choose whether to persist with Calum Chambers – who impressed against Forest – or restore Ainsley Maitland-Niles at right-back.
Emery has favoured a midfield diamond in their last two League away games – a 3-1 defeat at Liverpool and a 2-2 draw at Watford – and may do so again given the Gunners’ poor record at Old Trafford, where they have not won in the League since 2006.
A three-man defence or a more conventional 4-2-3-1 are possible alternatives but either way Pierre-Emerick Aubameyang will spearhead the attack, looking to extend his run of six goals in six League games.
Man Utd vs Arsenal predicted lineups
Man Utd (4-2-3-1): De Gea; Wan-Bissaka, Lindelof, Maguire, Young; McTominay, Matic, Pereira; Lingard, Greenwood, James
Arsenal (4-1-2-1-2): Leno, Chambers, Sokratis, David Luiz, Tierney; Xhaka, Guendouzi, Willock; Cebellos; Aubameyang, Pepe