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Arsenal will be without Pierre-Emerick Aubameyang and David Luiz for the Europa League visit of Vitoria as Unai Emery opts to rest the pair.
Neither trained on the eve of the Group F clash, although Alexandre Lacazette was involved as he aims for a first start since undergoing ankle surgery in September.
Gabriel Martinelli should start after notching two goals and assisting a third in the 4-0 win over Standard Liege in the last Europa League game.
Emery is likely to shuffle his pack for the game, with Emile Smith Rowe and Joe Willock likely to again be given minutes in the competition.
However, it remains to be seen if there is any place in the squad for Mesut Ozil, who has been controversially sidelined by the Gunners boss of late with just 142 minutes of action across all competitions this season.
Arsenal (4-3-3): Martinez; Bellerin, Mustafi, Holding, Tierney; Ceballos, Torreira, Willock; Maitland-Niles, Martinelli, Smith Rowe.
Vitoria (4-3-3): Silva; Sacko, Tapsoba, Henrique, Hanin; Poha, Agu, Evangelista; Edwards, Bonatini, Davidson.