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Mikel Arteta will be forced to make changes from the Arsenal team that drew 1-1 at Crystal Palace last week due to injury and suspension.
Sead Kolasinac has a thigh problem and as a result 18-year-old winger Bukayo Saka is likely to come in at left-back once again for this clash with high-flying Sheffield United.
The rest of the defence should stay the same, as should the midfield pair ahead of them – with Lucas Torreira overcoming a knock which forced him off at half-time against Palace.
In attack Arsenal will have to cope without Pierre-Emerick Aubameyang, who is serving the first of his three-game suspension after picking up a red card against Palace.
Reiss Nelson will most likely come in for the Gabon international, with Alexandre Lacazette leading the line and trusted with ending his goal drought.
Arsenal predicted lineup (4-2-3-1): Leno; Maitland-Niles, Sokratis, Luiz, Saka; Xhaka, Torreira; Pepe, Ozil, Nelson; Lacazette.