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Calum Chambers (knee), Pablo Mari (ankle), Gabriel Martinelli (knee) and Bernd Leno (knee) remain out for the Gunners, while Mesut Ozil (back) faces yet another late fitness check ahead of Wednesday’s clash with Liverpool.
Eddie Nketiah is still suspended, meanwhile, so Alexandre Lacazette will be confident of another start up front after his goal in the north London derby.
Mikel Arteta could alternatively play Pierre-Emerick Aubameyang centrally, of course, although that’s something he has generally resisted since his appointment in December.
Bukayo Saka could potentially return to the side to take Nicolas Pepe’s place down the right flank, although the versatile teenager is also an option on the opposite wing if Kieran Tierney is deemed in need of a breather.
Eight Arsenal players – Emiliano Martinez, the back three, the central midfield two, Tierney and Pierre-Emerick Aubameyang – have started all of the Gunners’ last four league matches, with Arteta sticking with a wing-back system for a run that was unbeaten before the defeat at Spurs.
Rob Holding and Sokratis are alternatives at centre-half and there is a strong possibility of rotation at right wing-back, with Cedric Soares now a positional rival to Hector Bellerin.
Saturday’s FA Cup semi-final against Manchester City looms large and there could well be further bodies preserved for that match, with Reiss Nelson, Joe Willock, Lucas Torreira and Ainsley Maitland-Niles hoping to get a look-in amid the fixture pile-up.